A research group at Osaka City University, in collaboration with Keio University, has revealed that there are characteristic changes in metabolites in the plasma components of patients with chronic fatigue syndrome, a disease of unknown cause.It seems to be an effective index for the objective diagnosis of chronic fatigue syndrome.

 Chronic fatigue syndrome is a disease in which a healthy social life cannot be spent for more than half a year due to severe fatigue and fatigue of unknown cause.Normal diagnosis and conventional medical examinations have not been able to detect the physical abnormalities characteristic of the disease, and no cure has been established.In severe cases, a biomarker (diagnostic index) that enables objective diagnosis has been sought because it causes a serious pathological condition that destroys the patient's life itself.

 This clinical study was conducted on two different subjects in different subjects.In Study 2, a metabolite characteristic of patients with chronic fatigue syndrome was discovered, and in Study 1, the validity of the results was confirmed.As a result of collecting plasma samples from these subjects and performing metabolome analysis (comprehensive analysis of metabolites), there were problems with the energy production system of the patient's cells and the metabolic dynamics in the urea cycle, and metabolites in the blood. It was suggested that the concentration of plasma may reflect the pathological condition of fatigue.Furthermore, the ratios of pyruvate / isocitric acid and ornithine / citrulline among the metabolites are significantly higher in patients than in healthy subjects, indicating that these can be effective biomarkers for the objective diagnosis of chronic fatigue syndrome. rice field.

 By combining the two ratios of the metabolites found in this study and using them as biomarkers, it is possible to objectively diagnose chronic fatigue syndrome.In addition, it is expected that studying changes in these metabolites will lead to the detailed elucidation of fatigue pathology and the establishment of treatment methods.

Keio University

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