A research group consisting of Professor Tsunehide Fuji, Associate Professor Yasuko Yamamoto, and Professor Kuniaki Saito of the Graduate School of Health Sciences, Fujita Medical University is collaborating with the National Institute of Infectious Diseases, Fuji Film Wako Junyaku, and Fuji Film. It was confirmed that the amount of antibody in the blood increased significantly by inoculating the new coronavirus vaccine manufactured by the company twice.
According to Fujita Medical University and others, the research group collected blood from 219 faculty members (69 men and 150 women) of the school before vaccination, 1 days after the first vaccination, and 14 days after the second vaccination. The amount of IgG, IgM, and IgA antibodies was examined.
As a result, it was found that all antibodies increased after inoculation, but IgG antibody in particular increased significantly after the second inoculation.When compared by gender, the amount of antibody in females was higher, and that in males decreased with age.
Furthermore, when it was investigated whether the blood of the inoculated person had a neutralizing activity that inhibits virus infection and proliferation, it was clarified that the larger the amount of IgG antibody, the higher the neutralizing activity.However, there were large individual differences in how antibodies that enhance neutralizing activity were produced.
The research group believes that continuous measurement of the amount of antibody in the blood may determine the individual vaccination interval, amount, and frequency of vaccination.In the joint research, we are developing a dedicated reagent that quickly and fully automatically measures the amount of IgG antibody, and the research group plans to proceed with a larger-scale investigation in the future.
