Bronchial asthma is a lung disease in which symptoms such as dyspnea and cough appear due to persistent airway inflammation, and treatment is performed in combination with multiple drugs, but no radical cure has yet been found.Since high-dose steroids, which have various side effects, are used for asthma attacks, it is desired to establish new preventive and therapeutic methods.

　On the other hand, the relationship between soybean intake and allergic diseases has been epidemiologically reported in the past, suggesting that soybean components may have some antiallergic effect.Imbalance, a fermented soybean product used in this study, has also been reported to be effective against atopic dermatitis and peanut allergies in animal experiments, but so far no effect has been reported on bronchial asthma.

　Therefore, this time, in this group, we investigated the effect of imbalance-added feed on asthma model mice on airway inflammation.

　As a result, it was confirmed that in the imbalance-administered group, the number of eosinophils, which are inflammatory cells in BALF (bronchial alveolar lavage fluid), was significantly reduced, and inflammation around the bronchi and mucus production were suppressed.It was also found that the expression of cytokines that induce eosinophil inflammation in BALF was also significantly suppressed in the imbalance-administered group as compared with the mice fed with a normal diet.

　With this discovery, Imbalance is expected to lead to drug discovery through further elucidation of the mechanism as a candidate for a new treatment method with fewer side effects than the current treatment method for bronchial asthma.Ingestion of fermented soybean products may also be useful as a complementary treatment in addition to current asthma treatments.

Paper information:[Nutrients] The Fermented Soy Product ImmuBalanceTM Suppresses Airway Inflammation in a Murine Model of Asthma