A group of Professor Takashi Nanada and Professor Akihiko Yoshimura of Keio University School of Medicine and Professor Satoshi Takahashi of the University of Tsukuba Medical School have discovered a new gene group that quickly converges the inflammatory response after cerebral infarction.

　Since cerebral infarction causes serious sequelae of neurological symptoms such as bedridden condition and lameness of limbs, it is expected to develop a treatment method to quickly resolve inflammation, but the mechanism of inflammation convergence has not been clarified so far. ..　

　This time, the collaborative research group has newly discovered a group of genes (Msr1, Marco, Mafb) that effectively eliminate pro-inflammatory agents produced in inflamed brain tissue.Furthermore, we found that the expression of these genes was increased by the leukemia drug tamibarotene.In mice with cerebral infarction, administration of tamibarotene accelerated the convergence of inflammation and improved neurological symptoms.

　In infectious diseases invaded by pathogens, inflammation subsides when the pathogens are sterilized and eliminated by immune cells, but since the brain is a sterile organ, such an inflammation convergence method cannot be applied.This study is expected to lead to the development of a new treatment method that accelerates the convergence of inflammation after cerebral infarction and improves the pathological condition by elucidating the mechanism for converging aseptic inflammation that does not involve pathogens such as cerebral infarction. Will be done.

Paper information:[Nature Medicine] Mafb prevents excess inflammation after ischemic stroke by accelerating clearance of danger signals through MSR1