The Hiroshima University Atomic Bomb Radiation Medical Science Institute has signed a joint research agreement with the bio-venture company Carna Biosciences (Kobe City) on the development of therapeutic agents targeting cancer stem cells for chronic myelogenous leukemia.Since recurrence of chronic myelogenous leukemia has become a major problem, successful development of new therapeutic agents is likely to be good news for patients.

According to Carna Bioscience, the joint research is on the findings of the institute's stem cell function research field, which is conducting research on hematopoietic stem cells from the perspective of regenerative medicine for intractable diseases of leukemia, and on the discovery of kinase inhibitors. Bringing together the know-how of Carna Bioscience.With the leadership of Associate Professor Kazuhito Naka of the Institute, we aim to create compounds that are new drug candidates targeting cancer stem cells of chronic myelogenous leukemia.

Tyrosine kinase inhibitors such as imatinib mesylate are commonly used and successful in the treatment of chronic myelogenous leukemia.However, in some patients, chronic myelogenous leukemia has not been completely cured and has recurred, which has become a major problem.
Recent studies have also revealed that cancer stem cells, which produce cancer cells, have attracted attention, and that there are a small number of cancer stem cells among leukemia cells.Cancer stem cells are also deeply involved in recurrence after treatment with tyrosine kinase inhibitors, and there is a need to develop new types of therapeutic agents that target cancer stem cells.

* Tyrosine kinase inhibitor A drug that interferes with the activity of an enzyme called tyrosine kinase, which is deeply involved in cancer growth.

Source:[Carna Biosciences Co., Ltd.] Notice of conclusion of joint research agreement with Hiroshima University Atomic Bomb Radiation Medical Science Institute (PDF)

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