Professor Kiyonao Sada, Professor of Genomics and Microbiology, University of Fukui, Physician and Graduate Student of Respiratory Medicine, University of Fukui, and other research teams reported on April 4, "Elucidation of the new natural immune mechanism of tubercle bacilli" I made a presentation.
About one-third of the world's population is infected with Mycobacterium tuberculosis, 1 people are affected and 3 people are killed in Japan.
This time, Professor Sada and Dr. Sada said that the receptor protein "Mincle" in the cell membrane of "mast cells", which is the source of releasing histamine that causes allergic symptoms such as pollinosis, accepts and acts on the components of tuberculosis bacteria. Announced for the first time in the world that it promotes the action of various proteins, activates internal immunity, and acts as innate immunity that protects our body from tuberculosis bacteria.
For the experiments, we used genetic engineering applications, drug inhibition experiments, and the latest genome editing technology for cell culture experiments.
Professor Sada said, "In the future, we hope to lead to the development of new preventive and therapeutic methods for tubercle bacilli and the design of molecular-targeted therapeutic agents."
Paper Information: [Scientific Reports] Association of C-Type Lectin Mincle with FcεRI βγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk
