A group at the University of Tokyo Graduate School of Agriculture and Life Sciences has discovered a substance that is thought to be the cause of nasal congestion (nasal congestion) caused by allergic rhinitis such as pollinosis.
Among the symptoms of allergic rhinitis, nasal congestion is a troublesome symptom that significantly lowers the patient's QOL and also causes sleep disorders.It is thought to be caused by an increase in blood flow and increased permeability of blood vessels running through the nasal mucosa, but the causative agent has not been clarified at this stage.
The researchers generated mice that developed allergic rhinitis by administration of ovalbumin.When the nasal cavity lavage fluid of this mouse was collected, a high concentration of 15-hydroxy eicosadienoic acid (15-HEDE) was detected. 15-HEDE is a lipid metabolite, but little is known about its bioactivity.
Therefore, when we conducted an experiment to treat the aorta from which 15-HEDE was removed from the mouse and the ear of the mouse, it was confirmed that the blood vessels were relaxed and the permeability was enhanced.In addition, when nasally administered to mice, symptoms showing thickening of the nasal mucosa and dyspnea appeared, and exacerbation of nasal congestion was observed.
From this, a large amount of 15-HEDE is produced in the nasal cavity of allergic rhinitis, and 15-HEDE causes relaxation of blood vessels and enhancement of permeability, resulting in swelling of the nasal mucosa, narrowing of the nasal cavity, and nasal congestion. The possibility was suggested.
It is said that allergic rhinitis such as pollinosis currently affects one in three people in Japan, and the number of patients is still increasing. 3-HEDE may be a substance that stimulates blood vessels in the nasal mucosa and causes spicy nasal congestion, and if this production can be suppressed, it is expected to be an epoch-making method for alleviating and treating nasal congestion. To.
Paper information:[The FASEB Journal] 15-hydroxy eicosadienoic acid is an exacerbating factor for nasal congestion in mice