A research group at Osaka University investigated the relationship between blood levels of fibroblast growth factor (FGF) 21, which is known to have anti-obesity effects, and lifestyle-related habits. It was revealed that habit affects the blood concentration of FGF21.

 So far, it has been reported that although FGF21 has anti-obesity effects such as improving glycolipid metabolism, serum FGF2 levels are conversely increased in obese and type 21 diabetic patients.It is thought that this is because obesity and type 2 diabetes are in a state of "FGF21 resistance", and the anti-obesity effect of FGF21 is reduced.

 On the other hand, since the relationship between serum FGF21 levels and lifestyle-related habits has not been elucidated, this study analyzed 398 men without underlying disease who underwent a health examination.

 As a result, it was discovered that lifestyle-related habits such as "do not eat much breakfast", "drink daily", and "have a smoking habit" change serum FGF21 levels.In particular, those who answered that they ate breakfast "0-2 days a week" and drunk "every day" had significantly higher serum FGF21 levels than those who answered other than that.In addition, smokers had significantly higher serum FGF21 levels than nonsmokers.Therefore, it is suggested that under lifestyle-related habits such as skipping breakfast, drinking alcohol every day, and smoking, the patient may become "FGF2 resistant" like obesity and type 21 diabetes, and the anti-obesity effect of FGF21 may decrease. rice field.

 Since it was found that lifestyle-related habits such as breakfast intake frequency, drinking frequency, and smoking habits may also affect the anti-obesity effect, it is expected that these lifestyle-related improvements will lead to the prevention of obesity.

Paper information:[Scientific Reports] Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects

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