The research group of Professor Koki Kamoi and Professor Kyoko Ohno of Tokyo Medical and Dental University is a joint research with the University of Tokyo and St. Marianna University School of Medicine. We found that even at low levels, severe eye inflammation (HTLV-1 uveitis) occurred.He pointed out the need to check for HTLV-1 infection if sudden vision loss occurs during the course of Graves' disease.
HTLV-1 (human T-cell leukemia virus type 1) is a causative virus that causes malignant tumors, etc., and is positioned as an important infectious disease that should be addressed worldwide by the World Health Organization (WHO) in 2020.Japan has the highest number of infected people among developed countries. Adult T-cell leukemia and HTLV-1-related myelopathy caused by HTLV-1 develop after middle age due to the long latency period from infection to onset, and have a high provirus load (infected cell rate: HTLV in all lymphocytes). -1 Content of infected cells) is known to be involved in the onset.However, it was unclear what factors contributed to the onset of HTLV-1 uveitis, a disease related to HTLV-1-.
This time, in the medical care of HTLV-1 uveitis patients, various tests and follow-ups showed that in the case of HTLV-1 carrier Basedou disease, even if the latency period is short and the provirus load is low, during the course of the procedure. It was found that HTLV-1 uveitis with severe vitreous opacity and retinal vasculitis developed.This pointed out the need to confirm the presence or absence of HTLV-1 infection when sudden visual loss is observed during the course of Graves' disease.
Currently, there are 100 million people infected with HTLV-3000 in Japan and 1 million people in the world, but it is thought that HTLV-1 infection is not so conscious at the time of medical treatment.Through this report, it is important to carry out medical treatment with the possibility that HTLV-1 infection is involved in the background of the medical condition.
Paper information:[THE LANCET] HTLV-1 uveitis and Graves' disease presenting with sudden onset of blurred vision
