Fertilized egg transplantation technology, which is one of the reproductive technologies, is a technology for transplanting fertilized eggs into the oviducts and uterus of females in which a pregnancy environment has been obtained to give birth to offspring. , Genome editing Widely used for the production of animals.Since rodents such as rats require a mating stimulus that creates a pregnancy environment prior to fertilized egg transplantation, males were required only to utilize the mating stimulus when using the fertilized egg transplantation technique.However, it is not always possible to copulate, and it is not always possible to obtain a female pregnancy environment.

　Therefore, the research group examined the reproduction of copulation stimulation using sonic vibration.In the experiment, a fertilized egg was transplanted into the oviduct of a rat whose pregnancy environment was created by sonic vibration.Observation confirmed that the fertilized egg was implanted in the uterus and then developed in normal offspring.There was no statistically significant difference in the birth rate of offspring compared to the comparison target.It took one night to create a pregnancy environment by copulation stimulus, but it could be reproduced in just 90 seconds by sonic vibration simulating copulation stimulus.

　It was proved that the newly developed sonic vibration device can create a sufficient pregnancy environment for rats.These research results can be used for other research animals such as mice, and can be applied not only to fertilized egg transplantation technology but also to elucidation of the mechanism of pregnancy, infertility research, and artificial reproduction of endangered species. It is expected.

Paper information:[Scientific Reports] Successful pseudopregnancy of rats by short period artificial stimulation using sonic vibration