Neuroscience: Personalized spinal cord treatment rapidly restores motor function after complete paralysis
Three patients with completely paralyzed sensory movements were given personalized spinal cord electrical stimulation using spatula-shaped electrodes specially designed for spinal cord injury within hours of treatment initiation. , It became clear that the movement movement by oneself will be possible again.The paper reporting this finding isNature Medicine Will be published in.Our findings clearly show that even with the most severe spinal cord injury, application-specific electrical stimulation therapy is highly effective and restores more diverse motor functions.
Electrical stimulation of the spinal cord is a promising therapeutic option for restoring motor function in patients with SCI.Previous methods have diverted techniques originally designed for the treatment of pain to apply continuous electrical stimulation to the patient's spinal cord.However, when the electrical stimulator is diverted in this way, it is not possible to stimulate all the nerves of the spinal cord involved in the movement of the legs and trunk, which may be a constraint and it may not be possible to recover all motor functions. ..
Now, Grégoire Courtine, Jocelyne Bloch and colleagues have designed a new spatula-shaped electrode that can target all nerves in the spinal cord involved in leg and trunk movement.By combining this technology with a personalized computerized framework, it has become possible to accurately position this spatula-shaped electrode for each patient and to formulate a stimulus program according to the activity for each patient.This optimized spinal cord stimulation method allows three patients with complete sensorimotor paralysis (all males, ages 3-29 years) to experience self-walking and other locomotions (biking, swimming) in just one day. It turned out to recover to.Furthermore, with the help of neurorehabilitation, patients are now able to perform these activities in real life.
These findings (part of the ongoing clinical trials) reveal the superior efficacy of application-specific personalized spinal cord stimulation and are clinically meaningful for patients with spinal cord injuries of varying severity. Treatments that can lead to improvement have been shown.
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Reprinted from: "Neuroscience: Individualized treatment of the spinal cord rapidly restores motor function after complete paralysis'
