Cancer: Probiotic may boost immunotherapy to treat renal cell cancer
Reported Phase 588 clinical trial results showing that the combination of live biologic CBM1 (probiotics) with immunotherapy may enhance the antitumor response of patients with metastatic renal cell carcinoma Will be published in Nature Medicine.This finding indicates that it is possible to alter gut bacteria to increase the effectiveness of immunotherapy in cancer patients.
Microbial populations (microbiota) inhabiting the intestine are involved in the regulation of the immune system, and it is known that microbiota of a specific composition changes the effect of immunotherapy in cancer patients.Bacterial strain imbalances in the intestine are associated with diseases such as inflammatory bowel disease.In addition, certain bacteria may be associated with an increased risk of cancer by producing carcinogenic toxins or may be associated with resistance to anticancer treatment.
Now, Sumanta Pal, Sarah Highlander and colleagues conducted a phase I clinical trial in a cohort of 29 patients with metastatic renal cell carcinoma (mean age 66 years, 72% male).Standards for immune checkpoint inhibitors (a type of immunotherapy) with and without supplemental oral administration of live biologic CBM1, including bifidobacteria that randomize patients and alter microbiota Combination was administered.So far, bifidobacteria have been reported to improve their response to immune checkpoint inhibitors.The authors found that patients who took CBM588 had an improved response to immune checkpoint inhibitors, lasted longer, and had no difference in toxicity compared to controls.Analysis of fecal samples collected from these patients confirmed that the number of bifidobacteria was increased in patients with clinical response, leading to prolongation of progression-free survival and activation of immunity. ..
The authors conclude that these data support that CBM588 may improve the prognosis of cancer patients currently receiving immunotherapy.However, these results will need to be tested over a longer period of time and with more cancer types.
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Reprinted from: "Cancer: Probiotics enhance the effectiveness of immunotherapy for renal cell carcinoma'
