A research group at Nagoya City University, in collaboration with Sapporo Medical University, Akita University, Mie University, and Okayama University, conducted a multicenter observational study to confirm that vaccination against the novel coronavirus is effective for Japanese breast cancer patients, and that it is effective for treatment planning. Although the effect is small, we showed that the effect may be weakened during chemotherapy and CDK4/6 inhibitor administration.

 In the epidemic of the new coronavirus infection, it is recommended that cancer patients, who are susceptible to infection, be vaccinated against the new coronavirus.However, the influence of cancer treatment on the effect, the difference in the effect in mutant strains, and the effect on the treatment plan of COVID-7 vaccination were not clear.Therefore, this time, we conducted a multicenter joint observational study at XNUMX facilities in Japan.

 Targeting breast cancer patients scheduled to be vaccinated against COVID-2021 from May to November 5, serum was collected before vaccination and 11 weeks after the second vaccination.The subjects were divided into groups of no treatment, hormonal therapy, anti-HER2 therapy, chemotherapy, and CDK4/2 inhibitor according to the treatment they received.

 As a result, the seroconversion rate after vaccination in breast cancer patients was 95.3%, which is equivalent to the past data of healthy subjects, and it was found that the impact of vaccination on cancer treatment is small.On the other hand, during chemotherapy and CDK4/6 inhibitor administration, it was suggested that the neutralizing antibody titer decreased depending on the mutant strain, and there was concern about the effect on long-term infection prevention.This suggested that actions for infection prevention are important even after two vaccinations.

 In the current study, getting the COVID-4 vaccine did not significantly affect cancer treatment regimens.However, it is unknown whether chemotherapy or CDK6/XNUMX inhibitor administration causes a decrease in the neutralizing antibody titer, and this is a subject for future investigation.

Paper information:[Breast Cancer Research and Treatment] Efficacy and impact of SARS-CoV-2 vaccination on cancer treatment for breast cancer patients: A multi-center prospective observational study

Okayama University

Promote the creation of an environment and system that can fly as a practitioner who can play an active role globally

A national university with 150 faculties, 10 graduate schools, and 8 research institutes, which is about 4 years old.Based on the results of advanced research activities, we can cultivate the ability of students to participate in "creation of knowledge" independently, and foster a rich humanity through close dialogues and discussions between students and faculty members. In a wide range of fields both domestically and internationally […]

Nagoya City University

Fostering excellent human resources who will lead the next generation, energetically challenging international and interdisciplinary research

Opened as a public university consisting of medical and pharmaceutical schools, it is now an urban university consisting of 7 faculties and 7 graduate schools. In 2016, the Graduate School of Economics "Medical Economics Management Course", the Graduate School of Medicine "Clinical Medical Design", and the Graduate School of Human Culture "Clinical Psychology Course" were established, opening up new academic fields. …]

Mie University

Bringing the power of Mie to the world Rooting in the region and producing unique educational and research results that can be proud of in the world-In harmony and symbiosis between people and nature-

We will develop human resources who can play an active role internationally with an interdisciplinary, original, and comprehensive perspective, as well as developing problem-seeking abilities, problem-solving abilities, and research abilities.Playing a role as a base for "knowledge" in the region that disseminates excellent research results, "promotion of human welfare", "coexistence of humankind in nature", "regional / international community […]

Sapporo Medical University

A world-leading medical university that combines tradition and achievements

Opened in 1950 as Hokkaido Medical University.For a long period of more than half a century, we have fostered medical personnel with rich humanity and have greatly contributed to the improvement of health, medical care, and welfare in Hokkaido.Currently, in response to the diversifying development of medicine and medical care, the medical school that is training clinical abilities and techniques and people's health are living […]

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