A research group at Juntendo University used the National Database (NDB), which contains the treatment history of almost all HIV-infected people in Japan, to conduct the first big data analysis of anti-HIV drug usage and continuation rates. Carried out.

 It has been found that Japanese people infected with HIV are getting older than they were 10 years ago.Along with this, the problem of comorbidity with age-related diseases and chronic diseases such as diabetes also emerges, so information on anti-HIV drugs that can be safely taken for a long time is very important.

 Against this background, this group conducted Japan's first database research on drugs for treating HIV infection.This research report analyzed 2011 HIV-infected people who received anti-HIV drugs between January 1 and March 2019, and analyzed the characteristics of changes in prescriptions for each drug. be.

 As a result of research, regarding the “key drug” that suppresses HIV, the prescription rate of integrase inhibitors has increased significantly since 2011, reaching 2019% in 95.Conversely, non-nucleoside reverse transcriptase inhibitors and protease inhibitors had a high rate of change and decreased prescription rates.The integrase inhibitor had the lowest drug change rate, indicating that it is a key drug that is difficult to change over a long period of time (easiest to continue).

 Next, for 'backbone' drugs combined with key drugs, year-to-year changes in prescribing rates were small, with tenofovir remaining at about 60%. Tenofovir/alafenamide fumarate use increased from 2017, accounting for 2019% in 70.

 Due to the increasing number of HIV-infected patients with comorbidities, it is expected that not only HIV specialists but also general/primary care physicians will prescribe these drugs in Japan in the future.The results of this big data analysis are expected to serve as useful indicators for the selection of appropriate therapeutic agents.

Paper information:[Scientific Reports] Analysis of antiretroviral therapy switch rate and switching pattern for people living with HIV from a national database in Japan

Juntendo University

Co-creating a new era with the keywords "sports" and "health"

A traditional school founded in 184 years.It is a comprehensive health university consisting of 7 faculties, 3 graduate schools, and 6 affiliated hospitals: Faculty of Medicine, Faculty of Sport and Health Science, Faculty of Medical Nursing, Faculty of Health and Nursing, Faculty of International Liberal Arts, Faculty of Health and Medical Sciences, and Faculty of Medical Science.Furthermore, in April 2023, we are preparing to open the Faculty of Health Data Science (tentative name) […].

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