Postoperative organ dysfunction due to ischemia during surgery is a problem in cardiovascular surgery such as aortic surgery that requires circulatory arrest.In particular, acute kidney injury is a major postoperative complication associated with increased mortality.Hypometabolism induction by ultrahypothermia below 20°C is used as an organ protection method during circulatory arrest, but hypothermia may increase the risk of postoperative bleeding and infection.

　Mice are non-hibernating animals that do not hibernate under normal conditions. induced hypometabolism: QIH).This indicates the possibility that humans, which are non-hibernating animals, can transition to a hibernation-like state.

　In this study, the joint research group set normothermic and hypothermic groups in mice in which hypometabolism (hibernation-like state) is induced by Q nerve activation (QIH mice) and control mice, respectively, and renal ischemia by aortic blockage. After induction, the degree of renal damage was assessed.As a result, we clarified that renal dysfunction can be partially prevented without hypothermia in QIH-induced renal ischemia model mice.

　In the future, if a method to induce QIH in humans can be developed, it may become a promising approach to achieve sufficient renal protection without hypothermia-induced circulatory arrest in cardiovascular surgery involving circulatory arrest. It is said that there is

Paper information:[JTCVS Open] Q neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest