A research group led by senior researcher Hidetoshi Masumoto of RIKEN, in collaboration with the Graduate School of Kyoto University, conducted an experiment to induce a hibernation-like state in kidney injury model mice associated with cardiovascular surgery.It was found that renal dysfunction could be partially prevented without hypothermia.In the future, it is expected to be a new organ protection method that replaces ultrahypothermia during human cardiovascular surgery.
Postoperative organ dysfunction due to ischemia during surgery is a problem in cardiovascular surgery such as aortic surgery that requires circulatory arrest.In particular, acute kidney injury is a major postoperative complication associated with increased mortality.Hypometabolism induction by ultrahypothermia below 20°C is used as an organ protection method during circulatory arrest, but hypothermia may increase the risk of postoperative bleeding and infection.
Mice are non-hibernating animals that do not hibernate under normal conditions. induced hypometabolism: QIH).This indicates the possibility that humans, which are non-hibernating animals, can transition to a hibernation-like state.
In this study, the joint research group set normothermic and hypothermic groups in mice in which hypometabolism (hibernation-like state) is induced by Q nerve activation (QIH mice) and control mice, respectively, and renal ischemia by aortic blockage. After induction, the degree of renal damage was assessed.As a result, we clarified that renal dysfunction can be partially prevented without hypothermia in QIH-induced renal ischemia model mice.
In the future, if a method to induce QIH in humans can be developed, it may become a promising approach to achieve sufficient renal protection without hypothermia-induced circulatory arrest in cardiovascular surgery involving circulatory arrest. It is said that there is
Paper information:[JTCVS Open] Q neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest