The joint research group of Kyushu University Graduate School of Science, Osaka University Graduate School of Science, and Kochi University of Technology Environmental Science and Engineering Group discovered for the first time in the world that the mismatch repair mechanism unwinds DNA from histon.
Accurate replication of chromosomal DNA is extremely important for living organisms.Misreplication causes mutations in genes, leading to canceration of cells and genetic diseases.To prevent this, we organisms have a defense system that repairs replication errors called mismatch repair, and when mistakes occur, proteins involved in mismatch repair gather on the DNA and scrape the DNA containing errors to obtain information. to repair.However, our human DNA is tightly wound and stored in a protein called histone, and it was a big mystery how the mismatch repair protein would access and correct DNA information in the event of an error. ..
Therefore, this time, the group investigated the structure of DNA when an error in DNA replication occurred.As a result, it was discovered for the first time that when replication errors occur, a DNA repair factor and a factor called Smarcad1 gather on the DNA to unravel the surrounding wound structure.
The mismatch repair mechanism has the function of preventing carcinogenesis and assisting the reaction of immune cells to make antibodies.Therefore, this result is expected to be applied to medical research such as cancer research caused by mismatch repair defects.
Paper information:[Genes & Development] Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1
