A research group led by Associate Professor Mayo Yasuki of the Graduate School of Osaka Public University, in collaboration with the Veterinary Clinical Center of Osaka Public University and the Research Institute for Microbial Diseases of Osaka University, extracted colistin and third-generation cephalotoxins from dogs kept as pets. For the first time in Japan, we discovered Escherichia coli resistant to both sporin antibiotics.
One of the designated resistant strains of human interest is third-generation cephalosporin-resistant Escherichia coli.Colistin is used for treatment because third-generation cephalosporin antibiotics are ineffective against this E. coli.The global spread of Escherichia coli resistant to both third-generation cephalosporin and colistin antibiotics is now a problem.On the other hand, drug-resistant bacteria have also been confirmed in pets, but research on the nature of drug-resistant bacteria in pets and the risk of two-way transmission between humans has not progressed.
In this study, 428 strains of bacteria isolated from 74 dogs and 687 cats with suspected infectious diseases that visited the Veterinary Clinical Center were investigated.As a result, we discovered two strains of E. coli that possess both a mobile colistin-resistant mcr gene and a third-generation cephalosporin-resistant blaCTX gene. proved to be tolerant.
Colistin-resistant E. coli has not yet spread to pet dogs in Osaka Prefecture, at least.However, there is a possibility that it will expand in the future, so continuous monitoring is essential.The source of the drug-resistant E. coli detected this time is also unknown.In the future, he hopes to develop research into a comprehensive evaluation that includes not only pets but also owners, the surrounding environment, and diet, and to assess the risk of transmission between humans and pets.
