Professor Naoki Hisamoto's research group at the Graduate School of Science, Nagoya University has conducted research using a nematode as a model, in which a protein that plays the role of a "reaper" that kills cells causes the severed nerves to "pretend to be dead." By doing so, we found that it induces the regeneration of cutting nerves, and elucidated the mechanism.

 It is known that organisms have a mechanism to eliminate themselves by dying unnecessary cells generated in the body.At its core is a protein called caspase, which, when activated, causes cells to die.In other words, caspase can be said to be the "reaper" who executes death.

 This time, the research group conducted an analysis using a nematode as a model to "do not kill" the nerve by caspase cutting only a part of a specific protein in the nerve where the axon was cut. We have found that only the signal "dead" is emitted to the outside.Furthermore, it was clarified for the first time that this "dead pretending" signal promotes nerve axon regeneration and induces nerve axon regeneration.

 The results of this research clarify the mechanism by which the protein that plays the role of the "reaper" that executes cell death promotes regeneration, which is a life phenomenon that is the exact opposite of death.The elucidation of this unexpected phenomenon has revealed a new mechanism for promoting regeneration that was not previously envisioned, and at the same time, revealed a new role of caspase in death and regeneration.

Paper information:[Nature Communications] Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration

Nagoya University

Aiming to be a person who has true courage and intellect and can open up the future

Nagoya University is a comprehensive university with 9 faculties, 13 graduate schools, 3 affiliated research institutes, nationwide joint usage, and 5 joint research centers.Through creative research activities, he explores the truth and produces some of the best intellectual achievements in the world.Foster courageous intellectuals with abundant logical thinking and imagination through educational practices that emphasize spontaneity […]

University Journal Online Editorial Department

This is the online editorial department of the university journal.
Articles are written by editorial staff who have a high level of knowledge and interest in universities and education.