In the field of organ transplantation and research on regenerated organs made from human cells, transplantation tests in many animals are indispensable before transplantation into humans.On the other hand, in order to verify the efficacy and safety of products such as regenerative medicine derived from human cells, preclinical studies (transplant tests) using not only mice and rats but also experimental animals such as pigs that are similar in size to humans. Was desired.However, it has been difficult to control the heterologous immune response that occurs when human cell-derived products are transplanted into pigs, making preclinical studies in pigs difficult.

　This time, the research group has succeeded in developing a pig model that can regulate immunodeficiency status by surgical methods.This model succeeded in engraftment of human tissue by simultaneously removing the thymus and spleen, which are important organs for the production and maturation of immune cells, in addition to the conventional administration of immunosuppressive agents.In addition, Saga University will use this technology to perform bypass transplantation into the carotid vein of a human cell-derived artificial blood vessel created with a bio 3D printer, and confirm the patency of the artificial blood vessel and the regeneration of vascular tissue for up to 20 weeks. I was able to.This demonstrated the effectiveness and safety of cell-made artificial blood vessels.

　The immunodeficient pig model successfully created this time can verify the efficacy and safety of products such as human cell-derived regenerative medicine.In addition, it is expected to be useful for research on creating human organs in pigs.

Paper information:[Nature Communications] Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes