A research group led by Professor Eiji Kobayashi of Keio University extracted hydrogen gas from an elderly miniature pig (donor) by quickly injecting hydrogen gas into the organ preservation solution in collaboration with Doctor's Man Co., Ltd. It was proved that the injured organ after a certain period of time can be revived into a transplantable organ with the blood flow stopped.
Organ transplantation from marginal donors (donors who do not meet standard donor conditions and have hypertension, obesity, etc.), including cardiac arrest donors, is an important measure to compensate for the shortage of organ donors and shorten the waiting period for transplantation.However, in marginal organs, in addition to organ thermoinhibition disorders (damage due to cardiac arrest / blood flow arrest at normal body temperature), cold storage disorders in organ preservation fluid cause strong ischemia-reperfusion injury at the time of transplantation. It is generated, and there is a high probability that a non-functional state will occur after transplantation.Therefore, it has been expected that the organ preservation solution is filled with hydrogen gas by a simple method to promote the functional regeneration of the damaged organ before transplantation and improve the prognosis after transplantation.
This time, the research group is able to safely inject hydrogen gas into a container containing an organ preservation solution from a hydrogen storage alloy canister used as a hydrogen gas storage device in just a few minutes. We have developed a new method to generate a preservation solution.In addition, the kidneys of an aged mini pig that had been injured due to continued circulatory arrest before removal were brought into contact with hydrogen gas in an organ preservation solution and resuscitated to a level where urinary excretion function could be maintained even after transplantation to another aged mini pig. I proved to let you.
This study focused on the postoperative acute phase, but in the future, it is expected to verify the long-term renal transplantation function under immunosuppressive administration and increase the success rate of transplantation of marginal organs.
