Previous studies in animals have shown that administration of NMN increases the amount of a substance called nicotinamide, adenine, and dinucleotide (NAD) that is present in various organs and suppresses age-related diseases. It was.However, in humans, it was unclear what effect NMN administration would have.

　In this study, 10 healthy men (40-60 years old) were given different doses (up to 500 mg) of NMN once each orally during the study period.There was no change in blood pressure / pulse after ingestion of NMN at all doses, and there was no change exceeding the standard value in blood / urinalysis to check the functions of the liver and kidneys.There was no effect on eye functions such as eyesight or sleep status.Furthermore, as the dose increased, so did the blood volume of metabolites made from NMN.

　From this result, it was found that the orally administered NMN is metabolized according to the dose administered in the human body and can be safely used in humans up to a single dose of 500 mg.So far, treatment methods that increase NAD in tissues have been studied with the aim of preventing diseases that increase with age. NMN is one of the leading candidates for activating a molecule called "sirtuin" that is said to be involved in longevity.

　This clinical study is expected to advance research on the prevention and treatment of diseases using NMN.A long-term administration study of NMN in healthy subjects is also planned.The development of clinical research is expected toward the realization of a scientifically-based nutritional approach by NMN for the treatment and prevention of age-related diseases.

Paper information:[Endocrine Journal] Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men