The research group of Professor Katsukatsu Kaneda of Kanazawa University Pharmaceutical Insurance Research Area, Professor Shuji Kaneko of Graduate School of Pharmaceutical Sciences, Kyoto University, Professor Akihiro Yamanaka of Research Institute of Environmental Medicine, Hokkaido University, and Professor Masafumi Minami of Hokkaido University Graduate School of Pharmaceutical Sciences is stressful. For the first time in the world, we have elucidated why the desire for cocaine increases.

 According to Kanazawa University, the research group focused on noradrenaline, a stress hormone, in the medial prefrontal cortex of the brain, which has been suggested to be involved in drug cravings.When we investigated the effects of noradrenaline on signal transduction and cell activity between neurons in the medial prefrontal area, we found that noradrenaline significantly increased excitatory neuronal signaling and enhanced neural activity.

 Furthermore, blocking the action of noradrenaline in the medial prefrontal cortex of mice was found to significantly suppress the stress-increased desire for cocaine.The research group believes that noradrenaline causes excessive excitement in the medial prefrontal cortex, resulting in an increased desire for cocaine.

 In drug addiction such as narcotics and stimulants, "relapse", in which the drug is stopped and then taken again, makes treatment difficult.There are various factors that cause relapse, and daily stress has been considered to be one of them.However, it has not been clarified where and how stress acts in the brain, leading to relapse.

Paper information:[Neuropharmacology] A cute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice

Nagoya University

Aiming to be a person who has true courage and intellect and can open up the future

Nagoya University is a comprehensive university with 9 faculties, 13 graduate schools, 3 affiliated research institutes, nationwide joint usage, and 5 joint research centers.Through creative research activities, he explores the truth and produces some of the best intellectual achievements in the world.Foster courageous intellectuals with abundant logical thinking and imagination through educational practices that emphasize spontaneity […]

Kyoto University

Foster a free academic style based on the spirit of "self-respect for self-weight" and open up a world of creative learning.

With the motto of self-study, we will continue to maintain a free academic style that is not bound by common sense, and develop human resources who have both creativity and practical ability.We provide an inclusive learning space that allows for diverse and hierarchical choices so that students themselves can choose a solid future through valuable trial and error. […]

Hokkaido University

Strong cooperation with industry and regions "Practical science unique to Hokkaido University" leads the world

The origin of Hokkaido University dates back to Sapporo Agricultural College, which was established in 1876.Throughout its long history, we have cultivated the basic principles of "frontier spirit," "cultivating internationality," "education for all," and "emphasis on practical studies."Based on this philosophy, he has a high level of academic background that is internationally accepted, and has accurate judgment and a leader […].

Kanazawa University

Flexible and flexible learning of specialized knowledge in a wide range of fields.Fostering human resources who will lead the global society

Kanazawa University, which boasts a history and tradition of more than 150 years, has a basic philosophy of "a research university that emphasizes education that is open to the region and the world," and is rich in humanity with specialized knowledge, problem-seeking ability, international sense, and ethical standards. By fostering talented human resources, we aim to become a "Kanazawa University that lives globally" and a "knowledge base in East Asia" [...]

University Journal Online Editorial Department

This is the online editorial department of the university journal.
Articles are written by editorial staff who have a high level of knowledge and interest in universities and education.