Takumi Hiyoshi, Associate Professor Hisatoshi Domon, Professor Yutaka Terao and Kobayashi Pharmaceutical Central Research Institute, Graduate School of Dentistry, Niigata University, have found that hinokithiol, a plant-derived ingredient, has a preventive effect on periodontal disease.It is expected to be applied to drug discovery because it is effective in melting bones that support teeth, inflammation of tissues, and proliferation of causative bacteria.
According to Niigata University, dentists Hiyoshi and his colleagues focused on the antibacterial activity of hinokitiol collected from plants such as hiba, and whether to give hinokitiol to mice with periodontal disease to suppress bone melting. , Observed by CT.
As a result, it was found that the melting of bones was suppressed and the causative bacteria in the mouth were reduced.In addition, genetic analysis of immune cells revealed that hinokitiol reduces the amount of biomolecules that cause inflammation.
Periodontal disease is known to exacerbate various diseases such as aspiration pneumonia, heart disease, and diabetes.When it becomes severe, the bones that support the teeth melt, which is the biggest cause of tooth loss in Japan.Periodontal disease is caused by the growth of bacteria in the mouth, causing inflammation.For this reason, research has been conducted on measures to suppress the growth of bacteria and prevent inflammation.
Dentists Hiyoshi and colleagues believe that the use of hinokitiol not only opens the way to more effective periodontal disease treatment, but is also effective in curbing the use of antibiotics.
Paper information:[Archives of Oral Biology] Protective effect of hinokitiol against periodontal bone loss in ligature-induced experimental periodontitis in mice
