A group of Professor Shinji Kamakura of Tohoku University has improved the method of producing biomaterials for bone formation performed in dental treatment and developed a new technology that enables bone formation using only biomaterials.It is expected to improve the stability of dentures and the treatment of periodontal disease.

 Teeth work well because they are surrounded by healthy bones.When a bone defect occurs in which the jaw bone becomes thin due to tooth extraction, various problems such as inability to bite occur, and bone regeneration by autologous bone grafting is required.However, even in the world, the technology (bone formation) that positively raises the bone on the surface of the bone has not been established with the biomaterial alone.

 In 2019, Tohoku University commercialized OCP / Collagen (Note), a biomaterial that can avoid autologous bone grafting for bone defects in the field of dental and oral surgery, through industry-academia collaboration.This biomaterial is an innovative biomaterial that promotes its own bone-forming cell differentiation and angiogenesis, realizes bone regeneration with properties equivalent to those of the original bone, is easy to use, and has excellent cost-effectiveness. there were.

 This time, the research group has developed an innovative bone formation technology that enables bone formation by OCP / Collagen alone by improving the pre-freezing conditions and density during OCP / Collagen preparation.It is necessary to achieve both "maintenance of the shape of the implant" and "new bone formation" for bone formation, but until now, even with bone formation using materials that are not absorbed in the body (non-absorbable materials), biomaterials alone are used. Even with bone formation, it was difficult to achieve both.The developed bone formation method utilizes the activation of its own cells, is a simple method, does not require additional surgery, and is more versatile than the conventional method.

 Based on the results of this research, we will apply it to the recovery treatment of bone defects caused by lean jawbone and periodontal disease, improve the stability of artificial teeth, support the placement of dental implants, expand the range of treatment such as improving periodontal disease, and further dentistry. It is expected to be applied to bone formation of bone tissue other than treatment.

Note: Composite material consisting of octacalcium phosphate (OCP) and medical collagen

Paper information:[Journal of Biomedical Materials Research Part B: Applied Biomaterials] Influence of pre-freezing conditions of octacalcium phosphate and collagen composite for reproducible appositional bone formation

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