Scoliosis, a disease in which the spine bends, is an idiopathic scoliosis whose cause cannot be identified in many cases.The most common idiopathic scoliosis is adolescent idiopathic scoliosis (AIS), which occurs in about 2% of Japanese people.A collaborative research group consisting of Shiro Ikegawa, team leader of RIKEN Center for Integrative Medical Sciences, and Professor Morio Matsumoto of Keio University School of Medicine announced that they have discovered a new gene "BNC2" related to the onset of AIS.
With the discovery of a new AIS susceptibility gene, it is expected that the elucidation of the cause and pathophysiology of AIS will progress dramatically.Furthermore, in the future, it is expected that functional analysis of BNC2 and detailed investigation of new pathways involved in the onset of AIS will lead to the development of new types of AIS therapeutic agents.
This research was conducted as a joint research with Kyoto University, Hiroshima University, and Nanjing University in China, and the results were published in the electronic version of the American scientific journal American Journal of Human Genetics.