A collaborative research team at the University of Tsukuba and the University of Tokyo has revealed that a small number of nerve cells (newborn neurons) that regenerate in the adult brain function to establish memory during REM sleep.

 It has been thought that lost nerve cells will never regenerate in the adult brain, but in recent years it has become clear that the hippocampus, a brain region deeply involved in memory, produces a very small number of new neurons even in adults. ..In addition, since sleep is known to play an important role in memory retention, in this study, we investigated the activity of newborn neurons during sleep in mice that were trained to experience fear while awake. By observing, we investigated the relationship between memory retention and the activity of newborn neurons during sleep.

 As a result, only the newborn neurons that were active during the scary experience reactivated during the dreaming period, REM sleep, even though the activity of the newborn neurons was generally reduced during sleep. It turned out that.Furthermore, when the activity of newborn neurons was manipulated by light stimulation in various ways, the mice forgot their fear memory only when the activity of newborn neurons growing for about one month after development was suppressed during REM sleep. It turned out that it would end up.Newborn neurons grow into complete neurons about two months after they are born from neural stem cells, but the same phenomenon does not occur in newborn neurons that have just been born or have grown up, and the activity of newborn neurons during non-rem sleep. No similar phenomenon was observed when suppressed.

 These results suggest that the activity of developing neoneurons during REM sleep is important for memory consolidation.In the future, by elucidating the mechanism by which newborn neurons establish memory during sleep, we will develop new treatments for diseases such as Alzheimer's disease in which neurons are lost and diseases such as PTSD that cause abnormalities in memory processing. It may be applicable.

Paper information:[Neuron] Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

Tokyo University

Established in the 10th year of the Meiji era.A university with the longest history in Japan and at the forefront of Japanese knowledge

The University of Tokyo was established in 1877 (Meiji 10) by integrating the Tokyo Kaisei School and the Tokyo Medical School.Since its establishment, it has developed education and research in a unique way in the world as a leading university in Japan and an academic center for the fusion of East and West cultures.As a result, many human resources have been produced in a wide range of fields, and many research achievements […]

University of Tsukuba

Continue to challenge interdisciplinary fusion and internationalization, and develop human resources with intelligence and humanity

University of Tsukuba is the core of Tsukuba Science City, an international city with a high academic and cultural scent.The current education system is 9 groups, 23 classes, and it is possible to take specialized introductory courses from all fields, aiming to have creative intelligence and rich humanity.Solving global issues with soul genius […]

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