The research group of Professor Kinichi Nakajima of Kyushu University is a study using mice at Tohoku University, Hoshi Pharmaceutical University, and the National Institute of Pharmaceutical Sciences and Food Hygiene. Clarified the impact.We also discovered that voluntary exercise is effective as an improvement method.

 Epilepsy is a chronic neurological disorder that causes convulsions due to excessive excitement of nerve cells.Pregnant women with epilepsy are given antiepileptic drugs to prevent seizures.While much research has been done on teratogenicity, research on its effect on brain growth in the long run has been delayed.For example, it has been reported that children born to pregnant women who received one of the antiepileptic drugs, valproic acid (VPA), have lower cognitive function than those who do not, but the cause has not been investigated. Is not ...

 In order for women with epilepsy to become pregnant and give birth with peace of mind, it is essential to elucidate these causes and develop coping strategies.The group conducted an experiment in which VPA was administered to pregnant mice.During the course of brain development, the stem cells that give rise to nerve cells must differentiate into nerve cells at an appropriate rate.However, we found that this mouse produced more nerve cells than usual and became depleted of neural stem cells.As a result, nerve cells could not be reborn at the required stage, causing learning and memory impairment.Furthermore, the mouse born in this way was made to perform voluntary exercise by a turning wheel.Then, it became clear that neural stem cells proliferate and the functional abnormalities of the brain can be improved.

 There are many points to consider in order to apply this finding to humans.In addition, by investigating the mechanism in more detail, we will explore ways to improve other than voluntary exercise.The details of the effects on humans and how to deal with them will provide new guidance for choices when giving birth while treating.

Tohoku University

Create excellent research results that will be the source of innovation, and develop talented human resources who will lead the next generation

Tohoku University has a rich culture and humanity based on the tradition of "research first principle" since its opening, the idea of ​​"opening the door" and the spirit of "respect for practical science", and is a phenomenon of human beings, society and nature. In response to this, human resources with the ability to carry out intellectual exploration with a "scientific mind", demonstrating their expertise in various fields from an international perspective and leading […]

Kyushu University

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Kyushu University, which celebrated its 111th anniversary this year, is a core university with 12 faculties and 19 faculties.We have been designated as a "designated national university corporation" that can be an international base by developing the world's highest level of outstanding education and research activities.From the humanities and sociology that we have cultivated so far to the natural sciences, and even the design-related "knowledge" […]

Star University of Pharmacy

Fostering "drug treatment professionals" with a wide range of education, rich humanity and affection

As a "Research and Education University", Hoshi University trains many "pharmacotherapy professionals" such as pharmacists who can spread the proper use of medicines to society and researchers who open up new possibilities for medicines.Based on the Faculty of Pharmacy, we have established two departments, "Pharmaceutical Department (6 years)" and "Pharmaceutical Discovery Science (4 years)", and have our own […]

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