Professor Takaaki Abe of Tohoku University, Professor Kenichiro Hayashi of Okayama University, Professor Hitoshi Kosaka of Jichi Medical University, and Professor Kazuto Nakata of University of Tsukuba have developed compounds that have the effect of suppressing the progression of mitochondrial disease, which is an intractable disease.As soon as the safety is confirmed, we plan to enter clinical trials for patients with mitochondrial disease.

 Mitochondria are one of the organelles in the cell.It plays the role of a factory that consumes oxygen and produces a substance called ATP that is used as an energy source in cells.Mitochondrial disease is a disease in which ATP is not produced intracellularly due to hereditary mitochondrial dysfunction, and about 700 patients have been confirmed in Japan.From early childhood, symptoms appear in various organs such as nerves, muscles, circulatory system, eyes, and digestive system, and while they progress quickly, there is no effective treatment.Until now, there was no countermeasure other than symptomatic treatment for the organs that had symptoms.

 A group at Tohoku University, who was analyzing blood substances in patients with uremia, discovered that some of the endogenous compounds have the effect of enhancing ATP production.Furthermore, when it was administered to cells of mitochondrial disease patients to investigate which compound had the effect, it was found that ATP was produced when the compound called MA-5 was administered.Furthermore, when administered to mice with mitochondrial disease as well as cells, it was confirmed that the life could be visibly extended.This achievement may lead to a therapeutic drug for mitochondrial disease for which there has been no cure.

 MA-5 has already entered the test to confirm safety, and domestic and international patent applications have been completed.As a new drug originating in Japan, it will greatly contribute to the development of the medical and medical industry.In addition, mitochondrial dysfunction is also associated with amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, diabetes, etc., so therapeutic effects on these diseases can be expected.

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Continue to challenge interdisciplinary fusion and internationalization, and develop human resources with intelligence and humanity

University of Tsukuba is the core of Tsukuba Science City, an international city with a high academic and cultural scent.The current education system is 9 groups, 23 classes, and it is possible to take specialized introductory courses from all fields, aiming to have creative intelligence and rich humanity.Solving global issues with soul genius […]

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Tohoku University has a rich culture and humanity based on the tradition of "research first principle" since its opening, the idea of ​​"opening the door" and the spirit of "respect for practical science", and is a phenomenon of human beings, society and nature. In response to this, human resources with the ability to carry out intellectual exploration with a "scientific mind", demonstrating their expertise in various fields from an international perspective and leading […]

Jichi Medical University
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Promote the creation of an environment and system that can fly as a practitioner who can play an active role globally

A national university with 150 faculties, 10 graduate schools, and 7 research institutes, which is about 4 years old.Based on the results of advanced research activities, we can cultivate the ability of students to participate in "creation of knowledge" independently, and foster a rich humanity through close dialogues and discussions between students and faculty members. In a wide range of fields both domestically and internationally […]

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