A research group led by Motoyona Kosaka, a graduate student at the University of Tokyo, found that inducing necrosis in fly wing cells affects the intestinal flora, resulting in a systemic inflammatory response and shortened individual lifespan. bottom.It is expected to lead to application to anti-inflammatory treatment.
Necrosis (cell necrosis) is said to release and diffuse substances that should be inside cells to the surroundings, causing an inflammatory response and greatly affecting health.The research group has succeeded in establishing a model that can induce local necrosis, and in this necrosis-induced individual, the innate immune response is simultaneously activated systemically and causes inflammation. Details were unknown.
In the study, aseptic flies were bred to investigate the contribution of the intestinal flora (bacterial flora) to the immune activation of necrosis-induced individuals.As a result, the immune pathway was significantly suppressed in the aseptic state.In addition, necrosis-induced individuals became short-lived with the activation of immunity, but this was also significantly improved by antibiotic treatment.This suggests that immune activation is associated with symbiotic microorganisms as well as endogenous factors derived from necrotic cells.
Then, when the intestinal flora was analyzed, an acetic acid bacterium called Gluconobacter was growing.This bacterium has been found to be the causative bacterial species that does not elicit an immune response in normal individuals, but causes an excessive inflammatory response and shortened lifespan in necrosis-induced individuals.
This time, we have revealed a part of the remote host-bacterial interaction that necrosis of tissues other than the intestine changes the intestinal flora and exacerbates the systemic inflammatory response.In the future, further elucidation of the malignant mechanism of diseases caused by disturbance of the intestinal flora and its application to medical treatment aiming at effective inflammation suppression are expected.
Paper information:[Cell Reports] Local necrotic cells trigger systemic immune activation via gut microbiome dysbiosis in Drosophila