A group of Keio University Medical Hyakuju Research Center, Kumamoto University, Gifu Pharmaceutical University and others has conducted a biomarker of cardiovascular disease by a cohort study of elderly people including "Super Sentinalians" who are over 110 years old. And found that plasma albumin is associated with ultimate longevity.
In recent years, the population of the elderly over 100 years has increased due to global longevity, but the number of super sentinarians is still rare, and by what biological mechanism the ultimate longevity is achieved. I don't know if it is.
本研究では、世界の高齢者の死因の第一位を占める心血管病に対する防御機構が、スーパーセンチナリアンの長寿の秘訣ではないかと考え、東京百寿者研究、全国超百寿者研究、TOOTH研究の3つの超高齢者コホート研究の統合データを解析し、36名のスーパーセンチナリアン、572名のスーパーセンチナリアン予備軍（105-109歳）、288名の百寿者（100-104歳）、531名の超高齢者（85-99歳）の計1,427名を対象に、心血管病に関連する血液バイオマーカーと生命予後（調査時点からの生存期間）の関連を検証した。
As a result, it was found that the neuroendocrine factor NT-proBNP, which is a biomarker of heart failure, is significantly associated with the prognosis of longevity independently of the risk of cardiovascular disease.In particular, it is strongly related to life expectancy after the age of 105, and it was found that the lower the blood concentration of this substance, the higher the possibility of reaching the age of 110 or older.
It was also found that plasma albumin concentration, which reflects nutritional status and is important as a predictor of prognosis in the elderly, is associated with total mortality in all age groups, and that the lower the albumin concentration, the higher the total mortality rate in all age groups. rice field.
This study reveals some of the biological characteristics of ultra-longevity people who are approaching their lifespan, and is expected to lead to the development of preventive and new treatments for cardiovascular disease in the elderly. NS.
Paper information:[Nature Communications]: Associations of Cardiovascular Biomarkers and Plasma Albumin with Exceptional Survival to the Highest Ages
