Research groups at the National Institute of Information and Communications Technology, Hokkaido University, and Osaka University have succeeded in developing a measurement method that captures how molecules rotate and diffuse in a solution.This may enable early diagnosis of cohesive proteins that are thought to be responsible for Alzheimer's disease.

 By measuring how the intensity of fluorescence emitted by a fluorescent molecule changes, it is possible to infer how the molecule is moving.It is also possible to estimate the size of the molecule from the moving speed.It is a widely used measurement method in cell biology, especially because it is suitable for investigating how intracellular proteins diffuse.However, until now, there was a problem that it was not possible to measure in a very short time.Therefore, it was difficult to capture the early stages of protein formation found in brain diseases such as Alzheimer's disease.The group has developed a superconducting nanowire single photon detector (SSPD) that solves these problems and is proceeding with performance evaluation.

 And this time, we succeeded in detecting a rod-shaped molecule called QRod, which has a diameter of 7 nanometers and a length of 22 nanometers (1 nanometer is 0.000000001 meters).We were able to observe how it rotates and diffuses in the solution in a very short time.From this, it can be expected that it is possible to detect even the initial stage of proteins formed in the living body.

 This time, the result is an artificially synthesized molecule, but in the future, we plan to conduct experiments using actual proteins.If established as a measurement method, it may be an extremely effective response for diagnosing neurodegenerative diseases such as Alzheimer's disease at an extremely early stage.

Osaka University

The "true value" of each person becomes the "evolution" of Osaka University.To a university that lives in the community and extends to the world

Osaka University is a research-based university with 11 faculties and 23 departments. Since its founding in 1931, with the motto of "living in the region and extending to the world," we have created an outstanding "foundation" and "power" that weaves advanced education and research capabilities, the harmony of faculty and staff, and the weight of tradition and the advantage of Osaka. I have.Taking advantage of these excellent potentials […]

Hokkaido University

Strong cooperation with industry and regions "Practical science unique to Hokkaido University" leads the world

The origin of Hokkaido University dates back to Sapporo Agricultural College, which was established in 1876.Throughout its long history, we have cultivated the basic principles of "frontier spirit," "cultivating internationality," "education for all," and "emphasis on practical studies."Based on this philosophy, he has a high level of academic background that is internationally accepted, and has accurate judgment and a leader […].

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