A research group at RIKEN and Kumamoto University has succeeded in elucidating a new mechanism by which the virus that causes AIDS spreads from cell to cell.It may lead to the development of new AIDS treatments that are completely different from conventional anti-AIDS drugs.
The duct that penetrates the cell membrane is thought to be the cause of infection by contact.By temporarily connecting these tubes, cells exchange substances necessary for their activities.But at the same time, it also transfers the virus.When we investigated how much contact transmission through this tube affected the spread of the infection, we found that about half of the spread was contact transmission.In addition, a closer look at immune cells infected with the HIV-1 virus revealed that the virus promoted tube formation.We also found that the protein M-Sec possessed by immune cells reacts with the protein Nef possessed by the virus to promote the formation of tubes.
This paved the way for a new treatment method that suppresses the function of M-Sec possessed by immune cells, inhibits the formation of tubes, and prevents the spread of infection.Until now, treatments targeting viruses have been the main focus, but in the future, creating an environment in which viruses cannot be transmitted by acting on the body may be the key to treatment.