As a result of comparing the seven genes involved in the new coronavirus infection from the database for each region / ethnic group, it was found that there was no difference between the regions / ethnic groups.It was found in a joint research between Hokkaido University, Boston Children's Hospital, and Harvard Medical School.
There are regional differences in the morbidity and mortality of the new coronavirus, and it has been shown that the mortality rate of African and Latin infected individuals is significantly higher than that of other races and ethnic groups, especially in the United States. There is.In this study, we will compare the seven genes involved in the infection of the new coronavirus from the database to see if there is a difference in genetic background as these factors, and to determine the genetic diversity between regions and ethnic groups. We investigated whether there was a difference in the mechanism of infection establishment.
Specifically, we comprehensively searched three large-scale human gene diversity databases and three whole-genome sequence databases, and found that there are regional and ethnic differences in the genes encoding the seven proteins involved in the infection of the new coronavirus. It is said that he investigated whether there was one.Furthermore, we examined whether there are functional differences between these seven proteins based on the gene sequence and protein structure / function information.
As a result, although there were slight gene diversity sequences (gene variants) for each region and ethnic group, none of them affected the function of proteins, and the frequency was extremely low. It was clarified that there is no regional or ethnic difference in function.
As a result, the differences in infection rates and the incidence of severely ill patients between regions and ethnic groups are not the important risk factors for the genetic differences analyzed this time, but rather environmental factors such as the medical history, age, and healthcare disparities of each individual. Was thought to be large.Further accumulation and analysis of genetic information related to such infections can be expected to lead to the development of medical measures such as the development of therapeutic agents.
Paper information:[Infection, Genetics and Evolution] A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3 / 7/8 across populations
