In recent years, it has been suggested that the function of immune cells may be changed by ingesting nutrients from food, which may affect the pathological condition of allergies.On the other hand, fatty acid-binding protein type 3 (FABP3) is a protein for transporting long-chain fatty acids that are insoluble in water inside cells, and is widely expressed in various cells in the body. The involvement with the pathology was unknown.

　The research group first examined the expression of the FABP3 gene in the immune cells of the immune system, the spleen, and found that FABP3 was expressed in some populations of lymphocytes (T lymphocytes).Therefore, when verified using mice lacking the gene that produces FABP3, the ears that induced allergic dermatitis were significantly swollen, and T lymphocytes that produced the inflammatory factor (IL-17) involved in the exacerbation of skin inflammation. Spheres (Vγ4 + γδT lymphocytes) were also accumulated.

　Furthermore, in juvenile FABP3-deficient mice, the proportion of Vγ4 + γδT lymphocytes in the thymus and skin was significantly increased.In vitro analysis revealed that some cells (DN3 cells) derived from the thymus of FABP2-deficient mice had markedly enhanced differentiation into Vγ4 + γδT lymphocytes.

　These results indicate that the disruption of lipid homeostasis during fetal and neonatal periods due to FABP3 deficiency promotes the differentiation of skin Vγ4 + γδT lymphocytes that affect the development of allergic disease in adulthood.The results of this research have the potential to provide new preventive and therapeutic strategies for allergic diseases in the future.

Paper information:[Allergy] Fatty acid-binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4 + γ / δ T cell in a murine model