Groups such as Keio University, Tokai University, Shiga University of Medical Science, and Ina Research Co., Ltd. performed uterine transplantation of cynomolgus monkeys and succeeded in giving birth after uterine transplantation for the first time in the world as a non-human primate animal.

 A woman with "uterine infertility", which is an infertility caused by having no uterus by nature or losing the uterus for some reason, cannot get pregnant or give birth on her own stomach.In response to this, research on a new medical technology called "uterus transplantation", which aims to give birth to a pregnant woman by receiving a uterus donated by a donor, began around 2000, and uterine transplantation has been performed on animals such as rats and sheep. Later births have been reported.However, pregnancy and childbirth in non-human primate animals that are anatomically and physiologically close to humans have not been realized.

 Since 2009, this group has been conducting uterine transplantation research using cynomolgus monkeys, which are non-human primate animals.It was thought that it would be difficult to create a uterine transplant model because the crab monkey weighs about 3 kg and is difficult to manage after surgery. ) Was systematically propagated, and a uterus transplantation model was created between pairs assuming the mother-daughter of MHC-controlled cynomolgus monkeys. succeeded in.

 The success of childbirth after uterine transplantation in cynomolgus monkeys in this study proved that uterine transplantation is technically possible, and the creation of an experimental animal model for the uterine transplantation also clarified the medical issues related to uterine transplantation. It's a big achievement that leads to.The group is aiming for the first clinical application of uterine transplantation in Japan, and is expected to bring hope to uterine infertile women.

Paper information:[Journal of Clinical Medicine] First successful delivery after uterus transplantation in MHC-defined cynomolgus macaques

Keio University
Tokai University
Shiga Medical University

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