Professor Takefumi Kikusui (Department of Applied Animal Science, Faculty of Veterinary Medicine) and Professor Kazutaka Mogi of the Center for Symbiotic Science of Humans and Animals, Azabu University have clarified the cause of dementia from the intestinal flora, and searched for biomarkers, preventive methods, and treatment methods. Research was started with the aim of establishing.
At Azabu University, the intestinal flora collected from patients with Alzheimer's disease was administered to sterile mice, and the notobiate mice were found to have impaired cognitive function compared to normal mice. Revealed.
In the future, using this notobioto mouse as a model, we will collect data on behavioral changes and changes in the intestinal flora due to antibiotic administration, etc., to identify the bacterial species involved in cognitive dysfunction with high accuracy, and to isolate the relevant bacterial species. We will elucidate the characteristics by culture and genome / gene analysis, and elucidate the molecular mechanism of bacterial-host interaction.We also aim to create new cognitive function improvement methods by controlling intestinal bacteria, establish preventive methods, and identify biomarkers.
