Collaborative research groups such as RIKEN announced that they have elucidated the mechanism of the onset of atopic dermatitis in model mice and discovered a method for preventing the onset with moisturizers such as petrolatum.This result is a collaborative research with Tokushima Bunri University, Suzuka Medical Science University, Kazusa DNA Research Institute, Kyoto University, Tokyo University, Keio Gijuku University, and Bio-Research Research Institute.

The collaborative research group administered "chemical mutagens" to mice to produce mutant mice.This mouse develops atopic dermatitis 8 to 10 weeks after birth even in a clean environment.When the gene mutation that causes the pathogenesis was investigated, a point mutation (one-base mutation) occurred in the gene sequence of the "JAK1" molecule, and the kinase activity, which is a phosphorylating enzyme of JAK1, increased (JAK1 molecule is found in various cells. Signal transduction factor of "cytokine" important for proliferation and differentiation).As a result, it was also found that the gene expression of the protease (peptide hydrolase) group expressed when the old keratin of the epidermal cells is peeled off before the onset is increased, and the skin barrier caused by the keratin is impaired.

 When JAK inhibitor was applied to the skin of these mice, the expression of protease was suppressed and the onset of atopic dermatitis was delayed.In addition, the onset could be prevented by applying Vaseline for an ointment substrate.At this time, the skin barrier function was maintained at the same level as normal, and the occurrence of inflammation in the dermis (fibrotic connective tissue under the epidermis) was suppressed.

 Using the mice produced this time, it is possible to clarify multiple factors involved in the onset of atopic dermatitis at the molecular and cellular levels, so it is expected to establish preventive and therapeutic methods for each target.

This study was published in the online version of the American scientific journal "Journal of Clinical Investigation" dated April 4.

Tokyo University

Established in the 10th year of the Meiji era.A university with the longest history in Japan and at the forefront of Japanese knowledge

The University of Tokyo was established in 1877 (Meiji 10) by integrating the Tokyo Kaisei School and the Tokyo Medical School.Since its establishment, it has developed education and research in a unique way in the world as a leading university in Japan and an academic center for the fusion of East and West cultures.As a result, many human resources have been produced in a wide range of fields, and many research achievements […]

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With the motto of self-study, we will continue to maintain a free academic style that is not bound by common sense, and develop human resources who have both creativity and practical ability.We provide an inclusive learning space that allows for diverse and hierarchical choices so that students themselves can choose a solid future through valuable trial and error. […]

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Aim to become a specialist at a comprehensive medical and welfare university.

Suzuka University of Medical Science is a comprehensive medical and welfare university with 4 faculties, 10 departments, 14 majors and 2 graduate schools.We are training medical and welfare specialists in advanced medical settings.We develop a variety of unique curriculums that transcend the boundaries of faculties and departments. In "medical personnel education", it is possible to cultivate only by education of specialized subjects [...]

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Tokushima Bunri University, which has a history and tradition of 125 years, is a comprehensive university with 8 faculties and 22 departments where you can study liberal arts, science, and medical science.Starting with general education that advocates liberal arts, we are working on education that allows us to acquire thinking ability, expressive ability, problem-solving ability through each specialized field, and to demonstrate the experience value in various situations. […]

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