A group from Hiroshima University and the National Institute of Infectious Diseases analyzed the oral flora of patients undergoing orthodontic treatment using a next-generation sequencer, and found that the oral flora of patients undergoing periodontal disease. It was found that the condition was similar to that of.
In orthodontic treatment, problems such as swelling of dental caries and gums may occur during treatment.All of these are infections caused by bacteria in the mouth, but previous studies investigating the relationship between orthodontic treatment and bacteria in the mouth have targeted only a limited number of bacteria.However, in recent years, the invention of the next-generation sequencer has made it possible to perform comprehensive analysis without limiting the bacterial species. Therefore, in this study, it is said that more than 700 types of bacteria inhabit the oral cavity. We evaluated how the flora changes with orthodontic treatment.
The researchers collected sap and plaque from patients who actually received orthodontic treatment at Hiroshima University Hospital in several batches during treatment, and analyzed the bacterial DNA collected from them using a next-generation sequencer. bottom.As a result, it was found that the bacterial flora of the mouth was significantly changed by wearing the fixed device used in orthodontic treatment.In both fluids and plaques, anaerobic bacteria, which contain many bacteria that cause infectious diseases, and difficult-to-culture bacteria that cannot be cultivated in the laboratory are increasing. The proportion of indigenous bacteria occupying the part was decreasing.
Furthermore, when these results were compared with the research reports of periodontal disease patients conducted using the same next-generation sequencer in the past, the above-mentioned changes in the bacterial flora caused by wearing orthodontic appliances were found in a healthy mouth. It was found to be similar to the transition from periodontal disease to periodontal disease.
In the future, we will prevent swelling of dental caries and gums that occur during orthodontic treatment by conducting long-term investigations such as changes in the bacterial flora several years or decades after the end of orthodontic treatment. It may lead to the establishment of a method.
Paper information:[Scientific Reports] The impact of fixed orthodontic appliances on oral microbiome dynamics in Japanese patients
