The University of Tokyo Institute of Medical Science has signed a joint research agreement with Astellas Pharma Inc. (President Yoshihiko Hatanaka, Tokyo) on an oral rice-type vaccine (mucorice) for Vibrio cholerae and toxinogenic Escherichia coli (* 1). tied.

 According to Astellas Pharma, Mucorice was developed by Professor Hiroshi Kiyono of the Institute of Medical Science, the University of Tokyo, and a specially appointed researcher, Yoshikazu Yuki, who expressed the toxin of Vibrio cholerae in the protein of rice by genetic recombination.We are conducting clinical trials at the Institute of Medical Science, University of Tokyo, and are compiling data.For clinical trials conducted under the joint research agreement, the Institute of Medical Science will provide samples and data, and Astellas Pharma will be in charge of clinical development.

 In developing countries, diarrhea caused by Vibrio cholerae and toxinogenic Escherichia coli is a major cause of infant mortality.The cholera vaccine currently used in developing countries requires a cold chain (* 2) and cannot be expected to be effective against toxinogenic Escherichia coli.Mucorice, on the other hand, is stable at room temperature and easy to manufacture, overcoming the problems of current vaccines.

 Through this joint research, the Institute of Medical Sciences and Astellas Pharma will work to develop vaccines for infectious diseases that affect developing countries, aiming to solve the problems of developing countries.

* 1 Toxinogenic Escherichia coli Escherichia coli that produces toxins that cause abdominal pain and diarrhea in humans.
* 2 A mechanism for storing and transporting vaccines while maintaining them at low temperatures in order to maintain the effectiveness of cold chain vaccines.

Tokyo University

Established in the 10th year of the Meiji era.A university with the longest history in Japan and at the forefront of Japanese knowledge

The University of Tokyo was established in 1877 (Meiji 10) by integrating the Tokyo Kaisei School and the Tokyo Medical School.Since its establishment, it has developed education and research in a unique way in the world as a leading university in Japan and an academic center for the fusion of East and West cultures.As a result, many human resources have been produced in a wide range of fields, and many research achievements […]

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