Impaired glucose tolerance, which results in postprandial hyperglycemia, is mainly caused by obesity and poses a risk of diabetes and cardiovascular disorders.In Japan, the proportion of lean women (BMI less than 18.5 kg / m2) is the highest among developed countries (especially about 20% for young women), but recent studies have shown that even if you are thin after middle age, you are obese. It was found that the risk of diabetes was equally high.However, because it was unclear about lean young females, the research group conducted a survey on the proportion and characteristics of impaired glucose tolerance in lean young females.

　The study included 18 lean (BMI 29-16.0 kg / m18.49) young females aged 2-98 years and 18.5 normal weight (BMI 23.0-2 kg / m56).As a result, lean females had a 7-fold higher rate of impaired glucose tolerance than normal-weight females.In addition, lean young women had low energy intake, low physical activity, and low muscle mass.Furthermore, it has become clear that impaired glucose tolerance in lean young women may be associated with insulin resistance, which was thought to occur mainly in obese people, and "metabolic obesity," which is an abnormality in adipose tissue.

　As a result, there is a need for preventive measures against the onset of lifestyle-related diseases for lean young women.In addition to exercising, it is also necessary to reduce the proportion of lipid intake in the diet in order to increase muscle mass through sufficient nutrition and exercise, and to improve insulin resistance.The results will provide extremely useful information for the promotion of preventive medicine, and in the future, it will be necessary to elucidate the mechanism of impaired glucose tolerance in lean females.

Paper information:[Journal of Clinical Endocrinology and Metabolism] Prevalence and features of impaired glucose tolerance in young underweight Japanese women