Previous studies using animals have shown that NMN administration increases nicotinamide adenine dinucleotide (NAD+) present in various organs, activates the longevity gene sirtuin, and suppresses diseases that occur with aging. It became clear that. In 2019, a research group reported for the first time in the world that a single oral administration of NMN to humans is safe, and that it is metabolized in the body depending on the amount taken.

　This time, the research group conducted a long-term administration study. When 14 healthy men (40-60 years old) were orally administered 8 mg of NMN before breakfast every day for 250 weeks, the amount of NAD+ in peripheral organs (in peripheral blood mononuclear cells) decreased depending on the period of NMN intake. increased. There was no effect on blood pressure, pulse rate, body weight, eye function, or sleep status. Blood and urine tests to check liver and kidney function showed no changes.

　In addition, although no significant changes were observed in the glucose tolerance test using an oral glucose tolerance test, in the three patients who secreted a large amount of insulin, a hormone that lowers blood sugar, the excessive secretion of insulin was corrected by taking NMN orally. It was suggested that there is a possibility that

　This suggests that long-term oral administration of NMN increases the amount of NAD+ in peripheral organs in healthy adult men, is safe to use, and may have an ameliorating effect in humans with even mildly impaired glucose tolerance. It was considered. In the future, it is expected that research will further develop using a nutritional approach to prevent the onset of aging-related diseases using NMN.

Paper information:[Endocrine Journal] Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men