A joint research team led by Professor Kosuke Kitagishi of Doshisha University has developed an emergency medical treatment that can simultaneously detoxify carbon monoxide and hydrogen cyanide, which are the causes of fire gas poisoning.Doshisha Women's University, Tokai University, Building Research Institute, and the University of Paris are participating in the research.
In fires, not only burns due to high temperatures but also toxic gases such as carbon monoxide (CO) and hydrogen cyanide (HCN) cause extensive damage.There is no cure for fire gas poisoning in emergency settings, and many lives are lost.In addition, simultaneous poisoning of CO and HCN increases the risk of death even at sub-lethal levels, but there is no treatment for this mixed gas poisoning.
Therefore, this time, the research group developed a synthetic compound "hemoCD-Twins" that will be a specific medicine for CO and HCN poisoning. hemoCD-Twins are composed of two heme model compounds (a mixture of heme iron and a cyclic oligosaccharide, cyclodextrin) in saline.Among them, hemoCD-P traps CO very strongly, and hemoCD-I effectively traps HCN and is rapidly excreted from the body.
In experiments, administration of this compound to mice co-intoxicated with CO and HCN resulted in a survival rate of over 85% (0% in the untreated group, i.e., all died), and rapid recovery from coma and exercise. resumed.Furthermore, when the compound was administered to mice that had been rendered nearly lethal by inhaling the fire gases generated by burning the acrylic material, the survival rate exceeded 80% (the non-administration group had a survival rate of about 40%). .In addition, this compound was excreted in the urine several minutes after administration and did not remain in the body at all.
The results of this research will lead to the development of therapeutic drugs that can increase the survival rate at fire sites and reduce the various aftereffects of fire gas poisoning.It is an epoch-making result that contributes to lifesaving and treatment of aftereffects from fire gas poisoning.
