In a study using mice, a research team led by Associate Professor Naoki Kumashiro and Assistant Professor Fumika Shigeyama of Toho University School of Medicine revealed that sleep disorders alter liver metabolism and increase hepatic fat accumulation.
Even a healthy person may have an abnormality due to a disorder in his / her lifestyle.In particular, in modern society, there is concern that the risk of lifestyle-related diseases such as diabetes increases due to lack of sleep.
To investigate the relationship between sleep and risk of diabetes, the research team used healthy mice as experimental animals, and said, "A group that was gently shaken and kept awake after 6 hours of sleep (sleep disorder group)" and "freely." They were divided into two groups, the "sleeping group (control group)", and both groups were given an unlimited high-fat diet and sugar water (to keep them in a diet similar to those with a disordered diet).
When the blood glucose level of the mice immediately after the sleep disorder and the fat mass of the liver were measured, the blood glucose level was significantly higher than that of the free-sleeping mice with only one 1-hour sleep disorder.It was also found that the amount of fat and glucose produced in the liver were significantly increased by sleep disorders.Furthermore, it was revealed that the gene expression of the enzyme responsible for hepatic fat metabolism was altered in sleep-disordered mice.
This achievement was not only published online in the American Journal of Physiology-Endocrinology and Metabolism of the American Physiological Society, but was also carefully selected and published monthly from articles published in 13 American Physiological Society-related scientific journals. Was also elected.
Paper information:[The American Physiological Society Press Release] Losing Just Six Hours of Sleep Could Increase Diabetes Risk, Study Finds
