Overlapping stress (chronic stress) causes various mental and physical illnesses such as cardiovascular diseases such as hypertension and mood disorders such as depression.On the other hand, exercise habits are known to be effective in preventing and improving various stress-induced diseases, but the mechanism is unknown.

　It is known that when inflammatory cells in the blood increase due to stress, some of them migrate to the brain and induce an inflammatory response.Therefore, the present group hypothesized that exercise habits might suppress the inflammatory response.

　To test this hypothesis, we examined blood pressure, gene expression, We measured and analyzed the leukocyte fraction and the number of inflammatory cells, and observed the effects of exercise habits on chronic stress-dependent hypertension.

　As a result, restraint stress significantly increased blood pressure in rats, increased bone marrow inflammatory response, increased blood inflammatory cells, and inflammatory cell infiltration in the blood pressure control center (hypothalamic paraventricular nucleus: PVN) in the brain. (move from blood to brain) was observed.On the other hand, in the stress + free exercise group, the peripheral (bone marrow and blood) inflammatory response was not improved, but the infiltration of inflammatory cells into the PVN was suppressed.In other words, it was suggested that exercise has the effect of suppressing stress-induced inflammatory responses in the brain, thereby preventing stress-dependent hypertension.

　In the future, it is expected to clarify how exercise prevents the infiltration of inflammatory cells into the PVN due to stress. It is expected to contribute to the elucidation of the effects of exercise on other diseases caused by inflammation in the brain.

Paper information:[Physiological Genomics] Impact of exercise on brain-bone marrow interactions in chronic stress: potential mechanisms preventing stress-induced hypertension