A research group at Okayama University, in collaboration with a group at Gifu University, demonstrated the dementia-preventing effect of the antioxidant combination drug TwendeeX (TwX) for the first time in the world through clinical trials, and oxidative stress is an important factor as a cause of dementia. Showed that there is.
In recent years, the number of patients with dementia has increased rapidly, and the development of new drugs for dementia is now an urgent issue common to the entire world.In the current medical care, it is not possible to take medication in the "pre-stage of dementia that is likely to become dementia in the future" (MCI: mild cognitive impairment). Has started.Moreover, existing drugs have many side effects and do not reliably stop their progression.
On the other hand, TwX is a supplement for which safety tests have been conducted, and it can be taken with confidence from the stage of MCI before the diagnosis of dementia, and it is expected to have a dementia preventive effect.
In this group, administration of TwX to cultured cells can reduce oxidative stress of cells and mitochondria, administration of TwX to mice can suppress the decrease in the number of newborn neurons, and oxidative stress and inflammation are suppressed in acute cerebral infarction model mice. It was confirmed that the infarct volume was reduced and that the decrease in nerve density was suppressed in the Alzheimer model mice.Based on these, we started clinical research on TwX in humans.
After 6 months of administration to Japanese MCI patients in a state where it was completely indistinguishable from genuine (TwX) and fake (placebo), the intellectual evaluation scales MMSE and Hasegawa scale were measured.As a result, it was confirmed that patients who took TwX had a significant improvement in both MMSE and Hasegawa scales compared to the start of taking TwX, which could prevent dementia in humans by suppressing oxidative stress. ..
TwX has received an A rating from the Evidence Creation Committee of the Dementia Prevention Society, and has become the world's first supplement certified by a public society as having a dementia prevention effect.It is expected to lead to the development of new therapeutic agents for dementia in the future.
