This group analyzed 21 Jack Russellterias with gastrointestinal polyps, characterized by the development of neoplastic polyps (adenomas / adenocarcinomas) in the stomach and large intestine, and being multiple, young. We also discovered characteristics that are different from those of normal canine gastrointestinal tumors, such as the onset of tumors in the large intestine.

　Focusing on the fact that this condition is similar to familial adenomatous polyposis, in which a large number of adenomatous polyps occur in the human colon, the group focused on familial adenomatous polyposis being a tumor suppressor gene mutation in the APC gene. Since it is a predominantly inherited disease caused by, we proceeded with the analysis of the APC gene even in affected dogs.As a result, an APC gene mutation (germline mutation) commonly found in affected dogs was identified, and it was found that this disease is a dominant genetic disease similar to human familial adenomatous polyposis.

　Since a specific APC gene mutation is found in affected dogs, it will be possible to make an accurate diagnosis by genetic testing in the future.This allows veterinarians to provide better treatment.In addition, if genetic testing is performed at the breeding stage, it is possible to control the occurrence of a genetic disease, so that this genetic disease can be reduced and eventually eradicated.

　Furthermore, in the field of research, it is expected that comparison of genetic diseases in dogs and humans will lead to further elucidation of the pathogenic mechanism and modifiers of gastrointestinal tumors.

Paper information:[Carcinogenesis] Familial Adenomatous Polyposis in Dogs: Hereditary Gastrointestinal Polyposis in Jack Russell Terriers with Germline APC Mutations