A research group at Osaka University Graduate School, in collaboration with Chukyo Hospital, has clarified that three proteins in the blood of severe burn patients are involved in survival and death (outcome).They were used to stratify patients and identify three subgroups by mortality.
In order to reduce the number of deaths from severe burns, it is necessary to elucidate changes in vivo.With the recent development of measuring instruments and integrated analysis (proteomics) technology, it has become possible to comprehensively analyze many proteins at once.However, until now, comprehensive measurements of blood proteins and proteomics in patients with severe burns have not been performed.
This time, the research group measured 20 kinds of proteins using mass spectrometry using the blood (plasma) of severe burn patients (642% or more of the burn area with a burn depth of second degree or more) on the day of injury. Comparisons were made between groups.
As a result, 10 proteins were identified that may be involved in survival and death (outcome) on the day of injury. In addition, we phenotyped severe burn patients based on the concentrations of these three proteins and identified three subgroups (phenotypes) associated with survival and mortality (outcome).
As a result, the subgroup with high expression of HBA1 and low expression of TTR and SERPINF2 had a very high mortality rate, and the subgroup with high expression of TTR and SERPINF2 had almost no mortality at 28 days after injury. ｡
These three proteins are expected to be not only prognostic markers that can evaluate changes in the body of severe burn patients, but also new therapeutic strategies and drug development according to phenotypes.
Paper information:[iScience] Combination of HBA1, TTR, and SERPINF2 in plasma defines phenotype correlated with severe burn outcome
