Fujita Health University and the National Institute of Technology and Evaluation (NITE), an independent administrative agency, analyzed protein and allergen information from molds and mushrooms present in air conditioners, and compiled this information into the Biological Resources Data Platform (DBRP) operated by NITE. ” announced that it was published on.
In diseases such as allergic asthma and allergic bronchopulmonary mycosis, it has been reported that inhaling fungi (molds and mushrooms) worsens the symptoms. There is little knowledge. Therefore, in this study, we investigated air conditioners in the homes of patients with allergic bronchopulmonary aspergillosis (ABPA), which causes asthma symptoms caused by mold, and analyzed what types of mold and mushrooms were present. They also analyzed the proteins (allergens) produced by these molds and mushrooms that cause allergies.
As a result, multiple molds, including Aspergillus species that are pathogenic to humans, were isolated and identified from air conditioners. In the proteome analysis, proteins were identified from these bacterial cells and culture fluid, and information on the identified proteins and allergens was published on DBRP.
Information on proteins and allergens detected from mold and mushroom cells and culture fluids actually collected from air conditioners is expected to contribute to the improvement of filters for air conditioners and air purifiers. In addition, if it is used for allergen testing in general clinical settings, it will become possible to diagnose patients who were previously undiagnosable, as well as to detect allergic asthma and allergic bronchopulmonary mycosis early before they develop, to prevent the disease from becoming more serious, and to reduce the severity of the disease. It is hoped that this will lead to further clarification.
