In recent years, when exposed to low nutrition not only in the fetus but also in newborns and infancy, it affects the formation of a predisposition to lifestyle-related diseases in adulthood, that is, the environment before and after birth affects lifelong health and illness. The "Developmental Origins of Health and Disease (DOHaD theory)" is drawing a lot of attention.However, the mechanism has not yet been elucidated.

　The research group of the Institute of Developmental Medicine, Kumamoto University has two enzyme pathways involved in metabolism, "NAD + -dependent deacetylase Sirt2 (NAD + -Sirt1)" and "FAD-dependent lysine-specific demethylase LSD1 (FAD-LSD1)". ) ”Was related to the mechanism of the DOHaD theory.

　The enzyme Sirt1 promotes the action of mitochondrial metabolism genes to induce an increase in metabolic activity and fat burning (thinness), and the enzyme LSD1 suppresses the action of mitochondrial metabolism genes to reduce metabolic activity and fat. Induces accumulation (obesity).When placed in a malnourished environment, Sirt1 first acts as an "immediate response" and consumes the stored nutrients to prioritize the maintenance of life, resulting in low birth weight.Next, LSD1 acts as a "predictive response" to form a constitution that makes it easy to store nutrients in preparation for future hunger.As a result, he explained the DOHaD theory, saying that if you are in an environment where you can get enough nutrition after birth, you will be more susceptible to lifestyle-related diseases such as obesity and diabetes.

　This consideration is expected to be useful for the development of new control and prevention methods for lifestyle-related diseases, which are important issues in modern society.It can also be said that it is important to have proper nutrition and living environment for parents during the conception period.

Paper information:[Trends in Endocrinology and Metabolism] Distinct roles of the NAD + -Sirt1 and FAD-LSD1 pathways in metabolic response and tissue development