The National Institute for Materials Science and a research group at Kagoshima University have developed a new wound dressing that closes wounds after gastrointestinal cancer treatment and promotes tissue regeneration.It is expected to be applied as a medical material to prevent accidental stenosis and bleeding after treatment for gastrointestinal cancer.
Endoscopic submucosal dissection (ESD), which removes early gastrointestinal cancers such as the esophagus, stomach, and large intestine with an endoscope, is attracting attention. ESD does not open the abdomen and can preserve other tissues such as the muscle layer.The problem is that the exposed submucosal tissue, which has been excised from the cancerous tissue, becomes highly inflamed and narrows.Currently, a sheet-shaped wound dressing is used to close the wound, but the tissue adhesion is low, inflammation occurs due to decomposition, and the sheet-like shape makes it difficult to reach the wound with an endoscope.
The research group has developed a particulate dressing that adheres firmly to living tissues and can be easily transported and sprayed with an endoscope.This coating material is prepared by chemically modifying pig-derived gelatin with a hydrophobic molecule having high tissue adhesiveness and forming it into particles by a spray-drying method.The particle size is very small and can be easily sprayed with a spraying device for endoscopes.When tested with porcine gastric mucosal tissue, the adhesive strength was about 10 times that of the commercially available product and about 2 times that of the unmodified gelatin particles that were not hydrophobic.Furthermore, when mixed with whole rat blood, blood coagulation was promoted.When sprayed onto the stomach of a mini pig that had an artificial ulcer, inflammation of the submucosal tissue was reduced and fibrosis of the submucosal tissue that causes stenosis was suppressed.In addition, since it is decomposed and absorbed in the body, there is no need for reoperation after tissue repair.
Since this material firmly adheres to living tissues and protects wounds, it is expected to be applied as a medical material that can prevent accidents after ESD.It is said that it plans to proceed with preclinical studies in the future.
Paper information:[Small] Multi-functional hydrophobized microparticles for accelerated wound healing after endoscopic submucosal dissection
